• Aberrant expression of HKII may be a required feature

  2022-07-12

  

  Aberrant expression of HKII may be a required feature for cancer development and progression. Overexpression of HKII has been reported in tumor tissues of cancer patients with liver [9], ovary [8], [24] and larynx [25]. The clinical significance of HKII in cancer was noted as overexpression of HKII

• In addition to the importance of heme as

  2022-07-12

  

  In addition to the importance of heme as an enzymatic cofactor, heme also acts as an important iron source. In order to access the iron within heme, S. aureus encodes heme degrading enzymes known as heme oxygenases (Skaar et al., 2004b; Wu et al., 2005). The two heme oxygenases encoded by S. aureus,

• In fact most PIs are susceptible to substitutions at

  2022-07-12

  

  In fact, most PIs are susceptible to substitutions at Asp168, which are often present in patients who fail therapy (Pawlotsky, 2016). Notably, the polymorphism Gln168 at this position underlies reduced efficacy of PIs against GT3 (Soumana et al., 2016a). Glecaprevir and voxilaprevir have improved re

• A common principle to ameliorate underquantification because

  2022-07-12

  

  A common principle to ameliorate underquantification because of primer or probe mismatching is to employ multiple targets for detection or quantification of blood borne viruses [14]. Dual targeting real time PCRs have become common for quantification of HIV-1 [15], [16]. In a recent paper arguing fo

• Several lines of evidence suggest that thermosensation in

  2022-07-12

  

  Several lines of evidence suggest that thermosensation in AFD is unlikely to be mediated by thermosensitive ion channels. AFD exhibits a steep temperature dependence with a reported Q of >1015 for temperature-evoked current, implying a strong amplification step in the thermotransduction process (Ram

• br Concluding remarks br Conflict of interest statement

  2022-07-12

  

  Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to

• While a role for YAP TAZ signaling in oligodendrocytes

  2022-07-12

  

  While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these Senexin B are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manner. Pla

• The DNA cleavage activity assay in the present

  2022-07-11

  

  The DNA cleavage activity assay in the present study also demonstrated the DNA glycosylase activities of SMUG1, NEIL1, TDG, and NTHL1 for 5OHU paired with A. While our findings on the activities of SMUG1 and NEIL1 were consistent with the results reported from previous studies [25], [50], the activi

• br Methods br Results and discussion Protein

  2022-07-11

  

  Methods Results and discussion Protein analysis of commonly used cell lines (C6, D54-MG, U87, U251 and STTG1) reveals high kinase inhibitors of SXC (Cho and Bannai, 1990, Ye et al., 1999, de Groot et al., 2005, Lyons et al., 2007, Savaskan et al., 2008). Since protein expression can be altere

• Post translational modifications of the GR can alter

  2022-07-11

  

  Post-translational modifications of the GR can alter the transcriptional effects of GR activation [31], and may provide a mechanism for the interactions between cell signaling pathways and GR-mediated transcriptional activity. Dex-BSA treatment reportedly increased p38 MAPK activation in CD14-positi

• Our data suggest that Slc a

  2022-07-11

  

  Our data suggest that Slc38a5 is important for amino-acid-induced α cell proliferation and expansion of α cell mass following GCGR inhibition, but not for formation and maintenance of α cell mass. This is supported by the finding that Slc38a5−/− mice have normal α cell mass. This is interesting sinc

• UMI-77 synthesis br Introduction Glucose homeostasis is prim

  2022-07-11

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β UMI-77 synthesis is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulato

• The relationship between estrogen and the Hedgehog pathway a

  2022-07-11

  

  The relationship between estrogen and the Hedgehog pathway as well as the associated mechanism have already been investigated in many tissues, especially in breast cancer (Chang et al., 2012, Katayama et al., 2006, Ramaswamy et al., 2012). Hitherto, even though we have proved that HH-Gli pathway pro

• In a meta analysis of genome wide

  2022-07-11

  

  In a meta-analysis of genome-wide association studies, a variant (rs10423928) in the GIPR gene has been found to be associated with elevated postprandial glucose and insulin (Saxena et al., 2010) as well as lean body composition including decreased BMI, lean mass and waist circumference (Lyssenko et

• br Funding Our work in this field was

  2022-07-11

  

  Funding Our work in this field was supported by CNRSLIA528, Agence Nationale de la Recherche 06-Neuro, Agence Nationale de la Recherche MNMP 2009. Introduction GABA and the GI motility The role of GABA in the modulation of GI motility is quite complex and not fully understood, since GABA-i

14637 records 387/976 page Previous Next First page 上5页 386387388389390 下5页 Last page