• It is well known that GPCR responsiveness desensitizes after

  2022-01-20

  

  It is well known that GPCR responsiveness desensitizes after prolonged exposure to agonists through several mechanisms such as receptor phosphorylation, arrestin binding and internalization (Dhami and Ferguson, 2006). Therefore, in the present work we decided to study whether group I-mGluR signaling

• br Results br Discussion Our cardiomyocyte specific

  2022-01-20

  

  Results Discussion Our cardiomyocyte-specific GR knockout mice did not show spontaneous cardiac hypertrophy unless pressure overload was given to the heart. This finding is somewhat different from previous work of a cardiomyocyte-specific GR A 804598 sale mouse model using GR-floxed mice with

• Ability of D Ala GIP to

  2022-01-20

  

  Ability of D-Ala2GIP to attenuate the neurobehavioral sequelae in QA-induced Huntington's disease model by reduction in lipid peroxidation, restoration of endogenous antioxidants and decreased striatal monoamine levels is of potential interest. Considerable preclinical evidence now exists of the pot

• CC is a widespread disorder

  2022-01-20

  

  CC is a widespread disorder affecting up to 20% of people worldwide, which also deteriorates the quality of life of patients and causes a substantial economic burden to society. There are 3 categories of CC: normal-transit constipation, slow-transit constipation and defecatory or rectal evacuation d

• Prior models suggest that the

  2022-01-20

  

  Prior models suggest that the terminal ends of the endocrine FGFs individually determine FGFR and KLB recognition, with little or no cross-talk. Our results confirm that short C-terminal sequences are necessary and sufficient to bind KLB and, supportive of a common mechanism, the underlying structur

• br Results and discussion br

  2022-01-20

  

  Results and discussion Conclusion In summary, we designed and discovered a series of novel GPR40 agonists containing 3,5-dimethylisoxazole with improved tPSA and ideal cLog P. Most of these compounds were confirmed as excellent GPR40 agonists in vitro. Especially, compound 11k exhibited robust

• br Discussion Our study found that

  2022-01-20

  

  Discussion Our study found that 62.6% of MSM from Natal had been tested for HIV before. This rate was higher than the national average of 37% estimated for the general kh7 in 2011 and the 51.6% found by Brito et al. in MSM from 10 Brazilian cities in 2009. These rates are rather disappointing as

• The proposed contributory role of endogenous

  2022-01-20

  

  The proposed contributory role of endogenous histamine via activation of H1 receptor in the locomotor sensitization induced by caffeine was further ratified by H1 receptor antagonism during the induction phase and subsequently its effect on expression to locomotor sensitization induced by caffeine.

• MAP Ks act at the level of

  2022-01-20

  

  MAP4Ks act at the level of MST1/2 to phosphorylate LATS1/2 and regulate the Hippo pathway (Box 1). Of particular interest is the involvement of MAP4K4, a key metabolic regulator [88] and common polymorphisms in the MAP4K4 locus are associated with T2D and insulin resistance [89] in adipogenesis. In

• br References and recommended reading

  2022-01-20

  

  References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Introduction Male sexual maturation includes gonadal maturation, secondary sexual characteristics, and the attainment of reproductive capacity [1]. Male sexual di

• 1423 br Materials and methods br Results br Discussion

  2022-01-19

  

  Materials and methods Results Discussion In this study, we demonstrated that zaprinast (a cGMP-PDE inhibitor) induced the intracellular calcium mobilization in the 1423 coexpressing GPR35 and Gqi5, Gqo5, or Gα16. Induction of intracellular calcium mobilization by zaprinast in the GPR35-exp

• Transcriptional translational modulators The discovery

  2022-01-19

  

  Transcriptional/translational modulators. The discovery that β-lactam antibiotics like ceftriaxone enhance the in vivo expression of EAAT2/GLT-1 [31] has pioneered a completely new approach to EAAT modulation, with several additional EAAT activators following in its trail (Figure 2b) [32, 33, 34•, 3

• br Results br Discussion ER

  2022-01-19

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• br Experimental section br Acknowledgements This study

  2022-01-19

  

  Experimental section Acknowledgements This study was supported by grants from the National Natural Science Foundation of China (Grants 81673299 and 81273376). Introduction Free fatty acids (FFAs) are important metabolic fuels and those that are polyunsaturated are essential components of t

• br Materials and methods br Results br

  2022-01-19

  

  Materials and methods Results Discussion Induction of neuronal cell death is the main neurotoxic mechanism of arsenite (Vahidnia et al., 2007). Previous studies have demonstrated that arsenite may trigger neuronal cell death via apoptosis, autophagy as well as necrosis (Yen et al., 2012; La

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