• Growth hormone secretagogue receptor GHSR is a member of G

  2021-09-03

  

  Growth hormone secretagogue receptor (GHSR) is a member of G-protein-coupled receptor family [3]. GHSR is predominantly expressed in human pituitary, rhypothalamus and hippocampus [4]. GHSR is also expressed in peripheral tissues including lungs, liver, kidney, and adrenal gland. In cardiovascular s

• IT-901 At this point it needs however

  2021-09-03

  

  At this point it needs, however, to be mentioned that most in vivo studies regarding the herein discussed nuclear receptors were performed in rodents, especially in mice. Due to the significant differences in metabolism in mice and humans, not all results are translatable between these species and h

• br Introduction Farnesoid X receptor

  2021-09-03

  

  Introduction Farnesoid X receptor (FXR) is a bile tosylate regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OSTα) that are

• In fish little information about Gpr

  2021-09-03

  

  In fish, little information about Gpr84 is available. We have revealed that lipopolysaccharide (LPS) induces significantly up-regulation of zebrafish , and zebrafish overexpression markedly increased the LPS-stimulated production of the cytokine []. Here we expanded on these studies to further inve

• Introduction Thrombotic disorders including ischemic

  2021-09-03

  

  Introduction Thrombotic disorders including ischemic heart disease, deep venous thrombosis, and ischemic stroke represent one of the most common causes of death in the world [1]. All these conditions relate to states accompanied by a shift of hemostasis balance into a coagulation side because of va

• In addition to lifestyle factors genetic factors may also in

  2021-09-03

  

  In addition to lifestyle factors, genetic factors may also influence the efficacy of antineoplastic drugs in breast cancer patients.16, 17 The HER2 gene contains several single nucleotide polymorphisms (SNPs). Two of the most investigated HER2 SNPs are Ile655Val (rs1136201) and Ala1170Pro (rs1058808

• Several bacterial functional pathways were observed after DO

  2021-09-03

  

  Several bacterial functional pathways were observed after DON administration, of which signal transduction, metabolism and genetic information processing displayed the highest levels of enrichment. Importantly, these three pathways were reported to be closely associated with DON's toxicity. Many evi

• br Acknowledgments Authors are thankful to the participants

  2021-09-03

  

  Acknowledgments Authors are thankful to the participants of the study for their cooperation. Financial support from Higher Education Commission (HEC) of Pakistan is highly acknowledged. AZ is supported by indigenous PhD fellowship from HEC. Indigenous PhD Fellowship for 5k Scholars batch 2 PIN NO

• In this study three potential

  2021-09-02

  

  In this study, three potential Otx-2 Ritodrine HCl were found in the promoter region of the sheep GnRH gene: −1786 bp to −1770 bp, −825 bp to −819 bp, and − 529 bp to −523 bp. Combined with the results of the double-luciferase assay, it could be inferred that the binding site of Otx-2 in the core p

• TKI-258 Materials and methods Standard curve for

  2021-09-02

  

  Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total

• Na K ATPase adenosine triphosphate

  2021-09-02

  

  Na+/K+-ATPase, clemastine fumarate receptor and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity was shown to be inc

• To maintain low Glu concentrations in the synaptic

  2021-09-02

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino apply for is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and in

• br Acknowledgements br Introduction Aminoacyl tRNA synthetas

  2021-09-02

  

  Acknowledgements Introduction Aminoacyl-tRNA synthetases catalyze the formation of an ester bond between an amino TCS 359 and the 3′ end of a tRNA in a two-step reaction. First, the amino acid is activated and an enzyme-bound adenylate intermediate is formed. Then, the amino acid is transferr

• The focused set of cyclopentapyrazoles produced six compound

  2021-09-02

  

  The focused set of cyclopentapyrazoles produced six compounds with sufficient activity to warrant the evaluation of kinetic solubility. Despite the improved activity of the series, these compounds remain stalwartly insoluble (), indicating the need for additional chemical modifications which address

• In contrast to inflammatory cytokines TGF has

  2021-09-02

  

  In contrast to inflammatory cytokines, TGF-β has immunosuppressive properties yet is also important for tissue imprinting immune cell function during development [23]. Salivary gland (SG) ILCs, in addition to liver and intestinal intraepithelial ILC1, express markers denoting tissue residency and TG

14692 records 567/980 page Previous Next First page 上5页 566567568569570 下5页 Last page