• In hypothalamus as indicated in Fig column A and following

  2024-08-19

  

  In hypothalamus, as indicated in Fig. 2 (column A) and following the enzymatic cascade represented in Fig. 1, we could hypothesize a predominance of Ang 2–10 and Ang III formation in SHR compared to WKY. This is in agreement with previous results that reported significant higher rate of Ang 2–10 for

• br Functions essentially consisting in transport of substrat

  2024-08-17

  

  Functions essentially consisting in transport of substrates across plasma membranes Direct activation of neurotransmitter transporters elicits responses in neurons As previously mentioned (Section 2.1), nerve terminals handling classical transmitters possess transporters able to (re)capture se

• br Functions essentially consisting in transport of substrat

  2024-08-17

  

  Functions essentially consisting in transport of substrates across plasma membranes Direct activation of neurotransmitter transporters elicits responses in neurons As previously mentioned (Section 2.1), nerve terminals handling classical transmitters possess transporters able to (re)capture se

• Our findings establish a critical link between HemAC Lm dime

  2024-08-17

  

  Our findings establish a critical link between HemAC-Lm dimeric structure and cAMP synthesis that helps in explaining how globin-A domain influences AC domain. The following possible homodimeric structure of wild type full length HemAC-Lm has been proposed to explain the role of this globin-A domain

• There has been growing interest over computational methods t

  2024-08-17

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it pkd kinase has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity relationship (QSAR)

• Although ACE genetic variance does not influence

  2024-08-17

  

  Although ACE genetic variance does not influence the level of bradykinin significantly, the bradykinin level tends to be affected by ACE inhibitor therapy used by patients. ACE inhibitor reduces the ACE activity that may lead to the accumulation of serum bradykinin. The level of bradykinin tends to

• Taniyama et al reported a female

  2024-08-17

  

  Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of Cy5.5 NHS ester was initiated using dexamethasone to control adrenal P p

• br Dual role of autophagy in

  2024-08-17

  

  Dual role of autophagy in human diseases Emerging evidence suggests that autophagy serves as a double-edged sword in several human diseases, such as CNS diseases (Rubinsztein et al., 2015), arteriosclerosis (Schrijvers et al., 2011) and cancer (Ozpolat and Benbrook, 2015). Likewise, currently the

• In the mammalian brain synapse formation

  2024-08-17

  

  In the mammalian brain, synapse formation is followed by a period of synapse refinement, and autophagy has been shown to play an important role in this process. For example, Tang and colleagues found that autophagy is required for the developmental pruning of dendritic spines, and that this pruning

• br Autophagy inducers Macroautophagy is

  2024-08-17

  

  Autophagy inducers Macroautophagy is often seen as a cellular process capable of increasing the fitness of Calcein AM receptor and overcome resistance to several forms of stress [9], [10]. As discussed above, it has been proposed by several authors that an effective strategy for enhancing sensit

• br Experimental section br Acknowledgment

  2024-08-16

  

  Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont

• A Belgian review on perioperative management of drugs recomm

  2024-08-16

  

  A Belgian review [9] (2011) on perioperative management of drugs recommends not using ACEI/ARBs due to the same reason. Another 2014 French [10] publication on the management of antihypertensive drugs in the perioperative period suggests withholding this medication before surgery even though they a

• MMP-2 Inhibitor I br Results and discussion In order to inve

  2024-08-16

  

  Results and discussion In order to investigate the assembly dynamics and aggregate structures of Aβ16-22, twelve molecular systems with the number of peptides varying from 1 to 12 were studied. In all simulations, the same peptide concentration (~15 mM) was maintained by adjusting the dimensions

• PGC mediated mitochondrial biogenesis in brown fat and endot

  2024-08-16

  

  PGC-1α-mediated mitochondrial biogenesis in brown fat and endothelial Gardiquimod is in part regulated by eNOS and NO [28], [29]. Recent studies indicate that H2S not only augments NO bioavailability and signaling [11], [17], but provides protection against cardiac injury in an eNOS-dependent manner

• Another issue is that the vast majority of data

  2024-08-16

  

  Another issue is that the vast majority of data from PET and CSF are from selected participants recruited through tertiary care dementia centers [176]. It is widely recognized that clinic-based participants differ from community-based studies, for example, the amount, type, and distribution of neuro

14198 records 65/947 page Previous Next First page 上5页 6162636465 下5页 Last page