• Based on both the observational and

  2020-11-19

  

  Based on both the observational and theoretical data generated in this study, it appears that the mechanism(s) underlying lower IFM CPT1 activity is complex. Modeling enzyme activity versus alterations in catalytic efficiency (Fig. 3A) suggests that the observed age-associated changes in Km and Vmax

• The availabilities of serotonin and

  2020-11-19

  

  The availabilities of serotonin and dopamine are modulated by the serotonin transporter and catechol-O-methyltransferase enzyme. The serotonin transporter (5-HTT) is a key protein that reuptakes serotonin from the synaptic cleft back into synaptic boutons (Coleman et al., 2016; Talvenheimo et al., 1

• The aim of the present

  2020-11-19

  

  The aim of the present study was to investigate the acute effects of THC on resting state gpr119 agonist neurophysiology, and to examine the impact of COMT genotype on these effects. Thirty-nine healthy volunteers participated in a randomised, placebo-controlled, crossover pharmacological MRI study

• br Casein Kinase II CK Casein

  2020-11-19

  

  Casein Kinase II (CK2) Casein Kinase II (CK2) is a ubiquitous serine/threonine-selective pro-oncogenic protein kinase that has become a more prominent target for research due to its effects and key role in tumorigenesis (Gowda et al., 2017a, Pinna, 2002). CK2, a well-conserved, pleiotropic kinase

• Phosphorylation of small GTPases has been also observed

  2020-11-19

  

  Phosphorylation of small GTPases has been also observed to affect binding affinity for the GDP/GTP cycle regulators notably GDP dissociation inhibitor (GDI) [10]. Indeed the EGF or cAMP-dependent phosphorylation of Cdc42 is associated with enhanced Cdc42–GDI interaction [8], [11]. RhoA inhibition by

• Although the mechanisms underlying the EP mediated increase

  2020-11-18

  

  Although the mechanisms underlying the EP4-mediated increase in the frequency of mEPSCs via PGE2 remain unclear, mechanisms similar to those driven by EP2 may be involved because activation of both these receptor subtypes increases the intracellular concentration of cAMP (Nishigaki et al., 1995, Sug

• hyPerFUsion™ high-fidelity PCR Kit br Conclusion The past fe

  2020-11-18

  

  Conclusion The past few years have witnessed substantial progress in understanding the structural mechanisms of substrate recognition and the reactions catalyzed by the O-GlcNAc-cycling enzymes, but more work remains. In particular, future research will be needed to establish how OGT and OGA inte

• Gossypol receptor In terms of its protease activity MME

  2020-11-18

  

  In terms of its protease activity, MME has a broad range of substrates being able to target glucagon, bradykinin, GLP1, and several other Gossypol receptor of circulating small molecules [25]. MME has been shown to target free insulin B-chain [32], although whether MME could target and degrade the

• In mammals NETs contain DNA and antimicrobial proteins

  2020-11-18

  

  In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48]. In fish, NETs-like structures have been observed, and DNA staining and immuno

• br Results br Discussion The

  2020-11-18

  

  Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i

• The ribosomal synthesis of D proteins is not

  2020-11-18

  

  The ribosomal synthesis of D-proteins is not currently feasible; the best effort undertaken so far was limited to the translational incorporation of two D-amino acids into the nascent protein chain by means of modified ribosomes (Dedkova et al., 2006). We therefore apply solid-phase peptide synthesi

• br Concluding remarks A crucial step in the

  2020-11-17

  

  Concluding remarks A crucial step in the microbial degradation of steroids is the 1(2)-dehydrogenation of the steroid nucleus by FAD-dependent Δ1-KSTDs. This step is required to initiate the opening of the steroid nucleus under both aerobic and anaerobic conditions. A large variety of steroid-deg

• br The contribution of Interference

  2020-11-17

  

  The contribution of Interference RNA and epigenetic in OA attenuation Interference RNA, a cellular mechanism for post-transcriptional gene silencing that is associated with mRNA. The potential of RNAi has successfully silenced the wide range of protein coding genes. Its high specificity sanctions

• br Materials and methods br Results br

  2020-11-17

  

  Materials and methods Results Discussion In general, CI symptoms are often visible only after the chilled products have been removed from coolstore to a warmer temperature (Schirra and Cohen, 1999). However, in the present work, 'satsuma’ mandarin fruit stored at 2°C showed chilling symptom

• br Cytokines and NK cells br Combined effects of cytokines

  2020-11-17

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK potassium channel blockers have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, surv

14637 records 731/976 page Previous Next First page 上5页 731732733734735 下5页 Last page