Everolimus treatment showed an increase

2019-07-26

Everolimus treatment showed an increase in the number of plaques and a reduction in plaque size, depending on concentration and treatment time (Fig. 1, Fig. 2).

There is a considerable molecular genetic

2019-07-25

There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions.

Ligand-independent constitutively

2019-07-24

Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases.

Introduction Localized degenerative and

2019-07-23

Introduction Localized, degenerative and progressive enlargement of the aortic diameter involves all layers of the vessel wall may ultimately rupture creating a catastrophic cardiovascular event [1,2].

In the present study we investigated

2019-07-22

In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G-proteins.

Results Diagrammatic representations

2019-07-19

Results Diagrammatic representations showing the bilateral injection sites in the BNST of all animals used in the present study are presented in Fig. 1.

Coactivator Binding Sets APC/C Catalytic

2019-07-18

Coactivator Binding Sets APC/C Catalytic Core in Motion A coactivator not only recruits substrates to APC/C [18] (Figure 3B), but also stimulates repositioning of the catalytic core 19, 24. High-resolution cryo-EM maps of apo forms of APC/C without a coactivator show the catalytic core and platform rigidified from the APC2–APC11 α/β domain and RING domain straddling the APC4 helical domain [53] (Figures 1C, 2A, and 4A,Box 1, and Video S1 in Supplemental information online).

O-GlcNAc transferase OGT belongs to

2019-07-17

O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-terminal catalytic region (Figure 1c) [16, 17, 18, 19, 20].

The three-dimensional crystal

2019-07-16

The three-dimensional crystal structure of Ca2+ loaded CaM reveals a dumbbell-shaped molecule with two roughly globular lobes, the N- and C-terminal lobes linked by a long solvent-exposed helix, which has been shown by NMR to be non-helical in its central part and flexible in solution [13].

LPS is the major toxic component

2019-07-15

LPS is the major toxic component of the outer membrane of gram-negative bacteria and high dose of LPS challenge in animal can induce a rapid systemic inflammatory response which resembles septic shock in clinical [15]. We demonstrated that administration of KPT330 significantly attenuated lung injury including interstitial oedema, haemorrhage, alveolar collapse, inflammatory cell infiltration and increased survival rate in LPS-induced septic mice.

There is a large interindividual difference

2019-07-13

There is a large interindividual difference in intestinal cholesterol AZ 10417808 of cholesterol that is mainly due to genetic variation [15], [19]. Single nucleotide variation (SNV) in NPC1L1 and, ABCG5 and ABCG8 key modulators of cholesterol influx and efflux into intestinal mucosal cells, respectively

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2018-07-29