• It was hypothesized that if modafinil

  2019-08-08

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

• Then what is the solution to tackle

  2019-08-07

  Then what is the solution to tackle DNA damage-induced metabolic decline The culprit here may be not DNA damage signaling per se, but rather the persistent activation of the DNA damage signaling pathways due to age-related accumulation of DNA damage.

• In this review focusing on biocatalyst

  2019-08-06

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic Trimipramine oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of formic acid oxidation and CO2 reduction with FDH are outlined.

• Introduction Maintaining the normal function

  2019-08-05

  Introduction Maintaining the normal function of fetal trophoblasts is essential for a successful pregnancy.

• In vivo study showed that the CYP3A

  2019-08-02

  In vivo study showed that the CYP3A activity was increased, when morroniside (10, 30 and 90 mg/kg, i.g.) was daily for seven consecutive days. Further, RT-PCR analysis showed that the induction of mRNA EX 527 by morroniside (10, 30 and 90 mg/kg, i.g.) was 1.13-, 1.43- and 1.79-fold higher, respectively, relative to the control.

• Substitutions on the benzene ring of

  2019-08-01

  Substitutions on the benzene ring of the phenyl acetic Bicuculline moiety were evaluated to study their effect on DP and CRTH2 selectivity.

• Our study demonstrated that the

  2019-07-31

  Our study demonstrated that the sequential events of PKA and AMPK activation were involved in kinsenoside-mediated lipolysis.

• Confidence with which data of animal

  2019-07-30

  Confidence with which data of animal safety/toxicity studies can be translated to human depends upon the knowledge that whether humans would be exposed to similar chemical entities (parent and its metabolites) as the animals exposed during toxicity studies.

• Our previous studies indicate that EBI2

  2019-07-29

  Our previous studies indicate that EBI2 is involved in the regulation of pro-inflammatory responses and inter-cellular communication under pathophysiological conditions such as LPS challenge (Rutkowska et al., 2016b).

• Structural changes within the heteromer

  2019-07-27

  Structural changes within the heteromer induced by agonist administration show a high level of complication.

• Everolimus treatment showed an increase

  2019-07-26

  Everolimus treatment showed an increase in the number of plaques and a reduction in plaque size, depending on concentration and treatment time (Fig. 1, Fig. 2).

• There is a considerable molecular genetic

  2019-07-25

  There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions.

• Ligand-independent constitutively

  2019-07-24

  Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases.

• Introduction Localized degenerative and

  2019-07-23

  Introduction Localized, degenerative and progressive enlargement of the aortic diameter involves all layers of the vessel wall may ultimately rupture creating a catastrophic cardiovascular event [1,2].

• In the present study we investigated

  2019-07-22

  In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G-proteins.

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