Confidence with which data of animal

2019-07-30

Confidence with which data of animal safety/toxicity studies can be translated to human depends upon the knowledge that whether humans would be exposed to similar chemical entities (parent and its metabolites) as the animals exposed during toxicity studies.

Our previous studies indicate that EBI2

2019-07-29

Our previous studies indicate that EBI2 is involved in the regulation of pro-inflammatory responses and inter-cellular communication under pathophysiological conditions such as LPS challenge (Rutkowska et al., 2016b).

Structural changes within the heteromer

2019-07-27

Structural changes within the heteromer induced by agonist administration show a high level of complication.

Everolimus treatment showed an increase

2019-07-26

Everolimus treatment showed an increase in the number of plaques and a reduction in plaque size, depending on concentration and treatment time (Fig. 1, Fig. 2).

There is a considerable molecular genetic

2019-07-25

There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions.

Ligand-independent constitutively

2019-07-24

Ligand-independent, constitutively active variants have also been found in receptors with associated tyrosine kinases.

Introduction Localized degenerative and

2019-07-23

Introduction Localized, degenerative and progressive enlargement of the aortic diameter involves all layers of the vessel wall may ultimately rupture creating a catastrophic cardiovascular event [1,2].

In the present study we investigated

2019-07-22

In the present study we investigated the effect of morphine withdrawal on G-protein coupling to opioid and ET receptors in neonatal rats. Morphine-induced G-protein activation was significantly higher in neonatal rats undergoing morphine withdrawal; suggesting enhanced coupling of the receptors to G-proteins.

Results Diagrammatic representations

2019-07-19

Results Diagrammatic representations showing the bilateral injection sites in the BNST of all animals used in the present study are presented in Fig. 1.

Coactivator Binding Sets APC/C Catalytic

2019-07-18

Coactivator Binding Sets APC/C Catalytic Core in Motion A coactivator not only recruits substrates to APC/C [18] (Figure 3B), but also stimulates repositioning of the catalytic core 19, 24. High-resolution cryo-EM maps of apo forms of APC/C without a coactivator show the catalytic core and platform rigidified from the APC2–APC11 α/β domain and RING domain straddling the APC4 helical domain [53] (Figures 1C, 2A, and 4A,Box 1, and Video S1 in Supplemental information online).

O-GlcNAc transferase OGT belongs to

2019-07-17

O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-terminal catalytic region (Figure 1c) [16, 17, 18, 19, 20].

The three-dimensional crystal

2019-07-16

The three-dimensional crystal structure of Ca2+ loaded CaM reveals a dumbbell-shaped molecule with two roughly globular lobes, the N- and C-terminal lobes linked by a long solvent-exposed helix, which has been shown by NMR to be non-helical in its central part and flexible in solution [13].

LPS is the major toxic component

2019-07-15

LPS is the major toxic component of the outer membrane of gram-negative bacteria and high dose of LPS challenge in animal can induce a rapid systemic inflammatory response which resembles septic shock in clinical [15]. We demonstrated that administration of KPT330 significantly attenuated lung injury including interstitial oedema, haemorrhage, alveolar collapse, inflammatory cell infiltration and increased survival rate in LPS-induced septic mice.

There is a large interindividual difference

2019-07-13

There is a large interindividual difference in intestinal cholesterol AZ 10417808 of cholesterol that is mainly due to genetic variation [15], [19]. Single nucleotide variation (SNV) in NPC1L1 and, ABCG5 and ABCG8 key modulators of cholesterol influx and efflux into intestinal mucosal cells, respectively

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2018-07-29