• In the current study cocaine did

  2019-08-26

  

  In the current study, cocaine did not significantly increase negative subjective effects and nepicastat did not increase these responses. This outcome is somewhat surprising given that the most commonly reported effect to date has been to increase the aversive properties of cocaine such as anxiety,

• br Introduction Protein modification by

  2019-08-26

  

  Introduction Protein modification by ubiquitin and ubiquitin-like proteins is one of the most common and important regulatory mechanisms in biology (Finley et al., 2004, Pickart, 2004). Ubiquitination is carried out by an enzymatic cascade consisting of three steps. In the first step, ubiquitin i

• It is reported that sympathetic nerve activity is increased

  2019-08-26

  

  It is reported that sympathetic nerve activity is increased in the SHR strain compared with that in the WKY strain (Judy and Farrell, 1979, Lundin et al., 1984, Sugimura et al., 2008) and NA content is increased in the CB of the New Zealand strain of hypertensive rat compared with that in normotensi

• In conclusion as illustrated in Fig G in response to

  2019-08-26

  

  In conclusion, as illustrated in Fig. 5G, in response to MNNG-induced DNA damage, PARP-1 appears to have dual roles in determining the cell fate in response to MNNG: PARP-1 activation is the cause of non-apoptotic cell death via ATP depletion and PARP-1 activation is able to elicit a self-protective

• br Introduction Plasmodium falciparum malaria

  2019-08-26

  

  Introduction Plasmodium falciparum malaria continues to be a major global cause of mortality and morbidity. Malaria treatment and control has been complicated by the emergence of resistance to widespread antimalarial drug use. The most common method for measuring antimalarial resistance is estima

• Multiple sequence alignment of the proteins in

  2019-08-26

  

  Multiple sequence alignment of the proteins in the DGAT1 sub-family shows that there are about 41 conserved amino Harringtonine residues distributed over seven sequence motifs [74]. Unlike DGAT2, a large number of DGAT1 residues, including a majority of the conserved residues, are found in a loop on

• One possible explanation for differences in the

  2019-08-26

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• E cadherin is an adhesive Ca dependent transmembrane protein

  2019-08-26

  

  E-cadherin is an adhesive Ca2+ dependent transmembrane protein mediating tight and strong cell-cell adhesion through homophilic interactions. There is strong evidence in favour of the major role of E-cadherin in melanocytes adhesion to keratinocytes in the WZB117 kinase (Tang et al., 1994). The exp

• br Conclusions Cereal seeds like the seeds of all

  2019-08-26

  

  Conclusions Cereal seeds, like the seeds of all plants, are responsible for the development, protection, dispersal, and nutrition of the next generation. Moreover, cereal caryopses have a high nutritional value for humans and animals. The stable and proper growth of cereal seeds is made possible

• To assess which export pathway is used by the

  2019-08-26

  

  To assess which export pathway is used by the iNOS mRNA, we inhibited CRM1 activity by incubation of DLD-1 Phosphatase Inhibitor Cocktail 3 (100X in DMSO) with LMB. Since LMB covalently and exclusively binds to CRM1, it represents a potent and specific inhibitor of the CRM1 transport activity [38].

• CRF and urocortin I are not only

  2019-08-26

  

  CRF and urocortin I are not only readily found throughout the spinal cord (Korosi et al., 2007), CRF analogs are clearly able to alter nociceptive signals (Imbe et al., 2010; Lariviere and Melzack, 2000). However, it was unclear whether they are released endogenously and involved in the spinal modul

• Organ fibrosis is thought to be

  2019-08-26

  

  Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial Dihydroartemisinin induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate t

• br Functional significance Defects of the lysyl hydroxylases

  2019-08-26

  

  Functional significance Defects of the lysyl hydroxylases LH1, LH2, and LH3 impair collagen secretion and stability in the extracellular matrix, and cause rare connective tissue disorders such as Ehlers-Danlos type-VI [27], Bruck syndrome [28], and skeletal dysplasia [29], respectively. Elucidati

• In this study CK C prepared from BL

  2019-08-26

  

  In this study, CK1δ(ΔC) prepared from BL21(DE3)pλPP had the highest kinase activity among the three isoforms tested when using casein as a substrate. Therefore, CK1δ(ΔC) from BL21(DE3)pλPP has the potential to be a “phosphorylating reagent” that may be widely used in experiments of phosphorylation a

• br Methods br Results br

  2019-08-24

  

  Methods Results Discussion The lowest intra-CeA dose of R278995/CRA0450 that prevented the elevations in NBOH-2C-CN hydrochloride reward thresholds associated with nicotine withdrawal was 0.05μg/side (0.1μg total bilateral dose). The total bilateral dose in the present study is 100 times

14637 records 965/976 page Previous Next First page 上5页 961962963964965 下5页 Last page