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Bufuralol Hydrochloride: Mechanistic Insights for β-Adren...
2025-09-23
Bufuralol hydrochloride, a non-selective β-adrenergic receptor antagonist with partial intrinsic sympathomimetic activity, is a versatile tool in cardiovascular pharmacology research. This article explores its mechanistic roles in β-adrenergic modulation studies, with a focus on advanced in vitro models and the implications for translational cardiovascular disease research.
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Annexin V-FITC/PI Apoptosis Assay Kit for Advanced Cell D...
2025-09-22
Explore the scientific applications of the Annexin V-FITC/PI Apoptosis Assay Kit in dissecting cell death pathways, early apoptosis detection, and necrosis in cancer research. This article highlights rigorous methodologies and novel insights for apoptosis assay optimization, with special relevance to renal cell carcinoma studies.
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Murine RNase Inhibitor: Safeguarding RNA Integrity in Adv...
2025-09-19
Explore the unique properties of Murine RNase Inhibitor, an oxidation-resistant mouse RNase inhibitor recombinant protein, and its critical role in RNA degradation prevention for sensitive molecular biology assays such as real-time RT-PCR and in vitro transcription.
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Anti Reverse Cap Analog (ARCA): Advancing Synthetic mRNA ...
2025-09-18
Explore how Anti Reverse Cap Analog (ARCA), 3´-O-Me-m7G(5')ppp(5')G, revolutionizes synthetic mRNA capping for enhanced translation efficiency and mRNA stability. This article delves into ARCA's biochemical advantages for in vitro transcription and its impact on mRNA therapeutics research.
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Anti Reverse Cap Analog (ARCA): Advancing Synthetic mRNA ...
2025-09-18
Explore how Anti Reverse Cap Analog (ARCA), 3´-O-Me-m7G(5')ppp(5')G, revolutionizes synthetic mRNA capping for enhanced translation efficiency and mRNA stability. This article delves into ARCA's biochemical advantages for in vitro transcription and its impact on mRNA therapeutics research.
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About this report Alzheimer s Disease Facts and
2025-03-03
About this report 2018 Alzheimer's Disease Facts and Figures is a statistical resource for U.S. data related to Alzheimer's disease, the most common cause of dementia. Background and context for interpreting the data are contained in the Overview. Additional sections address prevalence, mortality a
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Pregnane X receptor PXR is a nuclear receptor that plays
2025-03-03
Pregnane X receptor (PXR) is a nuclear receptor that plays an important role in regulation of metabolism and disposition of structurally diverse xenobiotics as well as endogenous steroids and bile acids (Bertilsson et al., 1998, Kliewer et al., 1998, Lehmann et al., 1998). PXR regulates the metaboli
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Qualitative inspection of the single channel traces presente
2025-03-03
Qualitative inspection of the single-channel traces presented in both Figures 3 and 4 shows that within bursts of activity, βAnc-containing AChRs display a marked reduction in open probability. To quantify these differences in single-channel behavior, we performed dwell-time analysis under high-reso
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Osteocytes the most abundant cells in an
2025-03-03
Osteocytes, the most abundant cells in an adult skeleton, are essentially mature osteoblasts that are surrounded by the products they secreted (Noble and Reeve, 2000). Osteocytes serve as mechanosensors that direct bone remodeling and that regulate the activities of osteoblasts and osteoclasts (Bone
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Using our infection assays we also explored whether low
2025-03-03
Using our infection assays, we also explored whether low-pH compartments were required for the entry of ZIKVs in mammalian cells. Lysosomotropic agents such as ammonium chloride, chloroquine and Bafilomycin A1, strongly inhibited the ability of ZIKVs to enter mammalian cells. Our results are in agre
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NOXA a member of the pro apoptotic B
2025-03-03
NOXA, a member of the pro-apoptotic B-cell lymphoma 2 (BCL-2) family, plays a vital role in regulating mitochondrial or inherent apoptotic pathways [7,8]. NOXA binds to MCL-1 with high affinity and interacts with A1 (known as BCL2A1), resulting in BIM release to trigger subsequent apoptosis [9]. In
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Consistent with a damaging role for increased LOX activity
2025-03-01
Consistent with a damaging role for increased 12/15-LOX activity in stroke, systemic administration of the 12/15-LOX inhibitor, LB1, 2 h after permanent focal cerebral ischemia significantly reduced infarct size 24 h after the ischemia, and the treatment group demonstrated improved behavioral and he
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br Introduction Melatonin N acetyl methoxytryptamine is
2025-03-01
Introduction Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone which is mainly secreted from the pineal gland. Melatonin is a highly conserved molecule present not only in vertebrates but also in nonvertebrates such as bacteria, protists, fungi, macroalgae, and plants (Cecon et al., 2017
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The crucial role of AP
2025-03-01
The crucial role of AP-1 in establishing and maintaining cell type-specific gene expression programs and cell identity is further apparent during reprogramming of mouse embryo fibroblasts (MEFs) into iPSCs with either Oct4/Sox2/Klf4/cMyc (OSKM ) factors , or chemicals . Using ATAC-seq to profile chr
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br Introduction Humans have consumed
2025-03-01
Introduction Humans have consumed mushrooms for centuries because of their high nutrient content and low lipid content, as well as their excellent flavor and texture [1]. Edible mushrooms possess notable medicinal properties and bioactivities, including antitumor, antiviral, antidiabetic, and ant